الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of this study was to evaluate the effect of sleep deprivation on vascular reactivity in adult male albino rats. This study was conducted on 140 adult male albino rats (200g +10). Rats were divided into four groups: Group (I): Control group. Group (2): Sleep deprived group. Group (3): Sleep recovery for 24 hours. Group (4): Sleep recovery for 48 hours. In each of the previously mentioned groups, systolic, diastolic and mean arterial blood pressures, vascular reactivity to noradrenaline, indomethacin, vasopressin, ACh and sodium nitropresside, serum adrenaline, noradrenaline, ACTH, cortisone and C ‐ reactive protein were studied. The results showed that induction of sleep deprivation was associated by significant increase in systolic, diastolic and mean arterial blood pressures, significant increase in the vascular reactivity to noradrenaline, vasopressin and indomethacin. The percentage of vasodilation to ACh significantly decreased. Serum levels of adrenaline, noradrenaline, ACTH, cortisone and C ‐ reactive protein significantly increased. In twenty four hour recovery group, systolic, diastolic and mean arterial blood pressures still significantly elevated. Also, vascular reactivity to noradrenaline, vasopressin and indomethacin were still significantly high. C-reactive protein also still significantly elevated, while adrenaline and noradrenaline returned to control levels. With eighty four hour recovery, blood pressure, vascular reactivity, C ‐ reactive protein, adrenaline and noradrenaline returned to control levels. |