الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Oral, oropharyngeal, and hypopharyngeal cancers are relatively uncommon malignancies constituting approximately 3% of all cancers worldwide. Oral cavity squamous cell carcinoma is the most frequent neoplasm in head and neck comprising nearly 30% of all malignant tumors in this region. Carcinoma of the hypopharynx is considered an uncommon malignancy and it has the worst survival rates among all other head and neck cancers. The present work was carried out to review medical records of all patients diagnosed with oral, oropharyngeal, or hypopharyngeal cancer and to identify the incidence of cases presenting to Alexandria main university hospital, stand on treatment modalities applied and survival outcome.
To achieve this aim, the present study included 255 patients diagnosed with oral, oropharyngeal or hypopharyngeal cancer. Those patients presented to Clinical Oncology and Nuclear Medicine Department, Alexandria Main University Hospital between January 2003 and December 2012. Medical records of the included patients were reviewed. Epidemiological data, clinicopathological data and details of various administered treatment regimens were retrieved and tabulated. Overall survival (OS) and disease free survival (DFS) of patients who were managed at our department were estimated using Kaplan-meier method.
In our study, oral, oropharyngeal, and hypopharyneal cancers constitute about 29.2% of head and neck cancers excluding thyroid cancer, and about 1.22% of all body tumors. 104 patients (40.8% of studied patients) were diagnosed with hypopharyngeal cancer, 53 patients (20.8% of studied patients) were diagnosed with oropharyngeal cancer, and 98 patients (38.4% of studied patients) were diagnosed with oral cavity cancer. The postcricoid region and the tongue were the most commonly involved primary subsites.
Mean age at diagnosis was about 52.91 ± 13.23 for hypopharyngeal cancer patients and about 54.40 ± 12.66 for oral and oropharyngeal cancer patients. 54.8% of hypopharyngeal cancer patients were females, and 43.0% of oral and oropharyngeal cancer patients were females. Positive history of smoking was found in 40% of all patients.
The most frequent signs and symptoms at presentation were regional LNs enlargement, dysphagia, ulcer, pain and weight loss. Squamous cell carcinoma (Sq.CC) was the most common histopathologic type among all studied patients constituting about 92.6%. Other types included lymphoma, adenocarcinoma and anaplastic carcinoma. Most of patients presented to our hospital were at advanced stage disease at diagnosis. 90.3% of hypopharyngeal cancer patients and 71.3% of oral and oropharyngeal cancer patients were at stage III, IV disease at presentation.