الفهرس 
acknowledgmentOnly 14 pages are availabe for public view
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Abstract
Sprague Dawely rat was specifically chosen as the experimental animal in this work because of its previous use as a standardized laboratory animal in toxicological studies. It suits also well in physiological investiga- tions, due to its large weight which gives a good chance to study each selected parameters individually.
Arsenic was the used toxicant used in the present investigation in its two forms, the trivalent (As+3) and the pentavalent (As+ The current investigation included bioassay, physio- logical, biochemical and therapeutic studies. Bioassay experiments: They were concerned with lethality studies for the determinations of the 96 hr.
and estimations of the minimal concentrations of the used antagonists treating arsenic-induced lethality. distribution of arsenic was extensively studied in blood, liver, kidneys, lungs, spleen, muscles, brain and heart of experimentals. In addition, determination of the percentage of the daily urinary and fecal excretion of this metal was carried out In the current study, difference in distribution between As and As could be seen after the first day.