الفهرس 
Liver cirrhosisOnly 14 pages are availabe for public view
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Abstract
Azza ZaghlolAzza Zaghlol Laboratory investigations which included the following: a) Liver function tests {total bilirubin, direct bilirubin, total protein, albumin, AST, ALT, alkaline phosphatase, GGT, INR for prothrombin time & concentration}. b) Viral hepatitis markers: {HBsAg & HCV antibodies}. c) Kidney function tests {serum urea & creatinine}. d) Complete blood picture. e) C. reactive protein 6) Serum IL-22 levels were measured by ELISA technique. 7) Abdominal paracentesis was done for studied patients with ascites & suspected to have SBP and ascetic fluid examined for PMNs. In our study, the majority of liver cirrhotic patients were males (72.5%) & old-aged patients. The mean age of patients was 56.15 ± 9.33 years old. Hepatitis C virus was the major cause of liver cirrhosis in our studied group of cases (72.5%) then HBV (12.5%), unidentified cause (cryptogenic) (10%), autoimmune (2.5%) & finally, primary biliary cirrhosis was found in about 2.5% of patients. About 65% of patients had history of bilharziasis. We found that the majority of patients presented with liver cirrhosis related complications at time of inclusion into the study. The most frequent liver cirrhosis related complication was ascites (72.5%). Esophageal varices were diagnosed in 50% of patients. 12.5% of patients had hepatorenal syndrome and 7.5% had SBPLiver & renal functions show statistical significant difference between studied groups of cases & control. According to Child-Pugh classification, we found only 5% of patients were class A, 17.5% of patients were class B & 77.5% were class C. Range of MELD score in patients was 7.41 to 34.12 with mean value 20.82±6.82. Interleukin-22 serum levels were significantly elevated in patients with liver cirrhosis when compared with healthy individuals with mean value 807.47 ±77.75 while in control group 4.88 ±6.19. Systemic IL-22 levels in patients with liver cirrhosis were not associated with their demographic characteristics (age, gender, residence, occupation, socioeconomic status and smoking). Notably, no significant differences became apparent between levels of IL-22 in the sera from patients with liver cirrhosis due to chronic HBV or chronic HCV. Interleukin-22 serum levels were significantly more elevated in patients with ascites, hepatorenal syndrome, SBP, hepatic encephalopathy & esophageal varices as compared to patients without these complications. In the present study, there was a significant positive correlation between high MELD score & serum levels of IL-22. Interestingly, IL-22 serum levels significantly correlated with MELD score, serum creatinine and INR but not with bilirubin.Interleukin-22 serum levels showed a statistically significant positive correlation with Child-Pugh score.Levels of ALT, alkaline phosphatase, albumin, total protein, urea and creatinine in the sera of patients and INR significantly were correlated with IL-22 serum levels. Serum levels of AST, direct bilirubin, total bilirubin and GGT didn’t correlate with IL-22 serum levels. Regarding CBC, hemoglobin, platelet and WBCs count were not significantly correlated with IL-22 serum levels.