![]() | Only 14 pages are availabe for public view |
Abstract Several studies indicate that the distribution and oomposition of plasma lipoproteins are related to the development of coronary heart disease. The coronary risk is positively correlated with plasma total cholestrol, triacylglycerol, and low-density lipoprotein LDL” cholestrol ooncentration but is inversely related to that of high-density lipoprotein NIDL” cholestrol. (Nikkila, et al. 1982) • The levels of various lipids and lipoproteins differ in the males and females of several species, including humans. (Barr, et al., 1951J Mo~itoh et aI, 1964; Nikkila, 1953; Rifkind et aI, 1978 and Wynn et al. 1969). These differenoes are magnified by hormone therapy. For example, exogenously administered estrogens and estrogen-containing oral ocnbaacept Lvea raise high density lipiproteih ”HDL”- cholesterol in women ~Bradley, et al. 1978 & Krauss, et al. 1979),and the levels of HDL-oholesterol attained are positively oorrelated with the estrogen oontents of the contraoeptive drugs (Bradley, et•al~ 1978). |