الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 175 |  |  |
| | | from | 175 | | |
Abstract
During low blood flow states, profound reductions in splanchnic blood flow and volume occur. The liver is partially protected from hypoperfusion by the hepatic arterial buffer response, the hydrodynamic interaction between the portal venous and hepatic arterial blood flow, tends to maintain liver blood flow under conditions of low mesenteric blood flow.
This study was carried out on 50 ESRD patients on regular hemodialysis for more than 6 months (3 sessions per week). The aim of this work was to evaluate effect of a single hemodialysis session with ultrafiltration on hepatic blood flow which is reflected by elevation of liver enzymes at the end of dialysis session and evaluated by Doppler hepatic blood flow. Our study showed that body weight, blood pressure showed significant reduction, while ALT and AST levels did not show significant reduction after HD session. On the other hand, portal vein blood flow and hepatic artery blood flow showed significant reduction after HD, in group II and III, with three or more liters ultrafiltration, but no significant reduction in group I, with one liter ultrafiltration. These results might suggest that ALT and AST are poor indicators for hepatic ischemia during HD, and that excessive ultrafiltration decrease hepatic blood flow, which is short term, but should be avoided.