الفهرس 
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Abstract
Our study aimed at assessment of the relationship between fatty liver and subclinical atherosclerosis in adolescents with type 1 diabetes mellitus for prediction and early prevention of cardiovascular disease for those group.
The study was a cross sectional study performed in pediatric department and radiology department in Suez Canal University Hospital.
We studied 110 children : 55 children with type 1 diabetes , 32 (58.2%) males and 23 (41.8%) females , range of age was from 11 to 18 years , mean duration of diabetes was (4.6±2.8) , and 55 healthy control subjects , 30 (54.5%) males and 25 (45.5%) females, range of age is from 12 to 16 years to determine the presence of increased subclinical atherosclerosis (measured as aortic intima-media thickness (aIMT) and its risk factors in children with type 1 diabetes.
We found 54.54 % abnormal liver finding (hyperechogenicity and / or hepatomegaly ) in type 1 diabetic group .Twenty five patients had hepatomegaly and tewleve had hyperechogenic liver .Adolescents with type 1 diabetes had significant increased liver size and echogenicity than control group. Liver size was increased in children with poor glycemic control than those with good glycemic control.
Although non significant, aortic intimal media thickness was increased in adolescents with type 1 diabetes than control group ,and it was significantly increased in adolescents with poor glycemic control than those with good glycemic control .
In our study, aIMT was found to be associated with several cardiovascular risk factors, suggesting that this method may be effective in detecting atherosclerosis in children and adolescents. In our study, age, triglycerides, liver size and HDL were positively correlated with aIMT .We found that the most predictor factors for aIMT were age, triglycerides and LDL.
Adolescents with type 1 diabetes had significantly higher level of triglycerides , HDL and LDL than control group. LDL, HDL and triglycerides were increased in adolescents with poor glycemic control than those with good glycemic control with statistically significant difference
Our results suggest that measurement of aIMT should be considered as a noninvasive method to objectively detect early atherosclerosis in adolescents. These could be important complementary tools to identify those at high risk, given the recent emphasis on prevention of atherosclerosis beginning in childhood .
We found a clear relationship between aortic intimal media thickness and liver size so fatty liver may predict early atherosclerotic changes in the aortic artery.