الفهرس 
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Abstract
The function of many metals in the thosues 4s to activate enaynes but this mst be done at fairly definite concentration: art concentration, then the moval may start to Anhibit the enzyme wae previously activating, or other enzynes, by Dlocking the active aites auch as slfoutydzyt groupe which are responsible for catalytic activity. In thin work, evidence was obtained invivo and invitro conditions denonatrating both inhibition and ennance went of alkaline phosphatase activity by both Cadniue and -wercury which were tine-and dose-dependent. mnaynes vary widely {n thotr ausceptibtiity to th action of heavy netale. Sore, such a catalase enzyre, are fully active Sn presence of tron, where this an ison-conta enayne (essential metal), bat others, completely inact svated (innioited) by none ential heavy retale. of these, stkaline Fhosphatase enzyme which is inhibited by cadetun fand sercury and Ss activated by certain essential or specific e tele, such as magnesium and tine, where it a zinc ‘containing enzyme, Purthe: At naa deen reported several Savestigators that aocenzynes are differentially inactivated by heavy setats (Broly, WithycoMDE, WA. Plunner, Wilkineon, Alkaline phosphatase (orthophoaphoric monoester shospho hyezoiase, widely disteieuted thougnout.