الفهرس 
Immunohistochemical localization of growth factors in SMGOnly 14 pages are availabe for public view
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Abstract
The submandibular salivary gland (SMG) is generally considered as an exocrine salivary gland. Although its main function is to secrete saliva, rat SMG has granular convoluted tubules (GCTs) that constitutively secrete many peptides, growth factors andhormones. Thus, SMG could be considered as a duacrine gland similar to pancreas in having both an exocrine and endocrine parts The latter function hypothesized that SMG could be involved inglucose homeostasis Diabetes mellitus (DM) is an endocrine disorder that affectsglucose homeostasis and results either from insulin insufficiency or sensitivity. Although, the exact destructive mechanism of DM is not fully understood, it is thought to be related to oxidative stresses accumulation. Among the different DM treatment modalities, ozone is claimed to regulate diabetic hyperglycemia and reduce oxidative stresses accumulation. Thus, we hypothesized that ozone could provide a better alternative than insulin in alleviating the diabetic burden on both SMG secretory parts and pancreas.