الفهرس 
OsteocalcinOnly 14 pages are availabe for public view
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Abstract
OBJECTIVE: To study the relation between insulin resistance and serum osteocalcin level among Diabetic patients with chronic HCV infection.
METHODS: 90 male subjects were recruited in our cross-section study. Their anthropometric parameters were measured and body mass index (BMI) was calculated. Serum markers including glucose, insulin, HbA1c, osteocalcin, AST, ALT, serum urea, serum creatinine, serum parathyroid hormone, total and ionized serum calcium and lipid profile. Insulin resistance was assessed by homeostasis model assessment (HOMA-IR). Subjects are divided into 30 subjects with type 2 diabetes mellitus with hepatitis C virus infection (T2DM+HCV), 30 subjects with type 2 diabetes mellitus (T2DM) without hepatitis C virus infection (T2DM-HCV) and 30 control healthy subjects.
RESULTS: Serum osteocalcin was lower in both (T2DM+HCV 23.8±8.9) and (T2DM-HCV 22.7±4.5) groups (P-value<0.001). Osteocalcin has a significant negative correlation with body mass index (r=-0.256 and P-value=0.041*), waist circumference (r=-0.3185 and P-value=0.013*), while has a significant negative correlation with fasting blood glucose (r=-0.531 and P-value<0.001*), 2h postprandial blood glucose (r=-0.67and P-value<0.001*), HbA1c (r=-0.74and P-value<0.001*), fasting serum insulin (r=-0.33 and P-value=0.02*) and HOMA-IR (r=-0.525 and P-value<0.001*).
CONCLUSIONS: Serum osteocalcin was decreased in subjects with type 2 diabetes both with and without HCV infection. Osteocalcin has a significant negative correlation with insulin resistance. Osteocalcin may have a relation with the occurrence of abnormal glucose tolerance.