الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
In older children and adults, sepsis is known to induce a variety of metabolic and endocrine changes that include increase serum cortisol and low thyroid hormones
In a study on meningococcal sepsis in children, the authors observed striking differences in the cortisol and thyroid hormone levels between the survivors and non-survivors The endocrinal alterations in sepsis are mainly regarded as non-specific response of the body, mostly mediated through cytokines and enzymes
Though neonatal sepsis is a common problem, reports on the neuro-endocrine changes in this condition is quite limited in literature
It is also not known, whether newborns react in the same way as adults in critical illness like sepsis. Some authors report the thyroid hormone and cortisol levels in neonates with sepsis in relation to the final outcome. It was hypothesized that during fulminant infections, the neuroendocrinal changes could be extreme and study of hormonal levels could act as some prognostic guidelines.