الفهرس 
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Abstract
The objective of this study was to investigate the relation between acne and insulin resistance in a sample of young males with acne. It included 25 male cases with different clinical patterns of acne vulgaris. They were selected from Dermatology outpatient clinic, Faculty of Medicine-Menoufia University hospital. A group of 25 age matched healthy male volunteers were selected as control group. Every patient was subjected to complete history taking, general examination, local examination of acne vulgaris, and laboratory investigations (Fasting blood glucose, Triglyceride, Cholesterol, Serum insulin level, free testosterone level and Sex hormone binding protein). The results of the present study revealed the following: Age ranged from 13 to 26 years and there was no significant difference between study and control groups. On the other hand, BMI ranged from 21.77 to 27.01 and there was significant increase of BMI in acne group when compared to control group. Systolic pressure ranged from 100 to 130 mmHg; while diastolic blood pressure ranged from 60 to 90 mmHg; and there was significant increase of both systolic and diastolic blood pressure in acne group when compared to control group. In the acne group, facial acne score ranged from 2 to 3; while facial acne score in control group was zero, thus, there was significant increase of facial acne score in acne group when compared to control group. As regard to lipid profile, cholesterol ranged from 160 to 175 mg/dl, while HDL ranged from 40 to 69 mg/dl; and finally triglycerides (TG) ranged from 70 to 92 mg/dl; and there was significant decrease of HDL and significant increase of triglycerides in acne group when compared to control group. Fasting glucose ranged from 75 to 110 mg/dl; while insulin ranged from 2.12 to 39.70 μU/ml and HOMA-IR ranged from 0.47to 9.31; and there was significant increase of fasting glucose, insulin and HOMA-IR in acne group when compared to control group. As regard to sex hormone binding globulin, it ranged from 15 to 50 nmol/ L and there was no significant difference between study and control groups. On the other hand, free testosterone ranged from 20.10 to 24.50μg/ml and there was significant increase of free testosterone in acne group when compared to control group (22.73±1.02 vs. 21.84±0.61 respectively). There was significant, positive correlation between HOMA-IR from one side and facial acne score and insulin from the other side. No other significant correlation was obtained.