الفهرس 
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Abstract
This study was designed to evaluate biochemical effect of ginger on hypercholestrolemic rats Study lasted for one month and was carried out on a total of 50 male albino rats of 200±10 g body weight were allocated into sex groups (5 rats for control and 9 for the others groups) as follow Group I : control : kept on basal ration and normal water Group II : Ginger aqueous extract: kept on basal ration and normal water + aqueous extract of ginger 400mg / kg Bwt and given daily by stomach tube Group III : Ginger ethanolic extract: kept on basal ration and normal water + ethanolic extract of ginger 400mg/ kg Bwt and given daily by stomach tube Group IV : Hypercholestrolemic or (control + ve): kept on basal ration and normal water and hypercholestrolemia was induced via intraperotineal injection of triton at dose of 250mg/ kg 3 times/weeks Group V : Aqueous + hypercholestrolemic: kept on basal ration and normal water + aqueous extract of ginger and hypercholesterolemia was induced via triton injection Group VI : Ethanolic + hypercholestrolemic: kept on basal ration + and normal water ethanolic extract of ginger and hypercholesterolemia was induced via triton injection Blood sample were collected from eye canthus of rats of all groups after one month and serum was separated for determination of Serum lipids profile and calculation of atherogenic indices Liver function tests Hormones Cardiac functions, Na and K Liver tissues were collected for determination of Liver weight (g) and liver/ body weight (% Liver was taken for Tissue histopathology Our results and statistical analysis revealed the following Injection of triton in rats induced hyperlipidemia. As, it significantly increased serum TC, TG, vLDL-c, LDL-c and TL while, it markedly decreased HDL-c as compared to control group - Trearment with aqueous and ethanolic extracts of ginger showed potent hypolipidemic activity - Hypercholestrolemic rats had high atherogenic indices - Treatment of hypercholestrolemic rats with both ginger extracts lowered these indices -Liver weight was significantly increased in hypercholestrolemic rats. However, the addition of both ginger extracts significantly decreased this increase - Treatment with both ginger extracts was able to improve liver function through decrease of liver enzyme activities Hypercholestrolemic rats had significant increase of serum ALT, AST, ALP and LDH. Treatment of hypercholestrolemic rats with ginger (aqueous and ethanolic) extracts produce significant decrease of serum ALT, AST , ALP and decrease LDH Addition of (aqueous and ethanolic) extracts of ginger significantly increase testosterone, progesterone and increase estradiol. While, not affect T3 and T4 Hypercholestrolemic rats had significant increase of serum testosterone, progesterone, estradiol, T3 and T4. Treatment of hypercholestrolemic rats with both ginger extracts produce significant increase of Testosterone, T3 and T4. While, progesterone and estradiol not affected -Addition of both ginger extracts significantly decrease of CK-MB, K and decrease Troponin (I). While, Na not affected by ginger presence -Hypercholestrolemic rats had significant increase of CK-MB and Troponin while, Na significantly decreased and K not affected. Treatment of hypercholestrolemic rats with both ginger extracts produce significant decrease of serum CK-MB, Troponin (I) and K. While, Na not affected Liver tissues of the (control, GAE and GEE): showed normal histological criteria of the hepatic cords and hepatocytes. While, in hypercholestrolemic rats liver showed, marked fatty change of the hepatocytes -Liver from rats treated with both extracts of ginger showed mild fatty changes as compared to hypercholestrolemic rats.