الفهرس | Only 14 pages are availabe for public view |
Abstract Dyslipidemia is an important risk factor for coronary artery disease. There is strong relationship between total cholesterol or LDL cholesterol levels, HDLand risk for coronary artery disease events. In our study we used coronary MDCT scan to evaluate 100 patients of mean age 54.34 ± 11.04, 69% males presented with symptoms suggestive of coronary artery disease (chest pain syndrome) along with full fasting lipid profile analysis. All the study population were statin naïve. MDCT scan allowed to evaluate the number, site, volume,extent and density of coronary artery plaques, more over it allowed their classification according to the type of plaques (calcified, or non-calcified) and significance of stenosis. We found that total serum cholesterol, LDL cholesterol and serum triglycerides were higher in the subgroup having non-calcified plaques than those with calcified ones and were significantly higher in the subgroup with significant than those with non-significant stenosis. These three parameters demonstrated also had a highly significant negative correlation with the mean density of the plaques. HDL cholesterol was lower in the subgroup having noncalcified plaques than those with calcified ones and had a strong negative correlation with the significance of stenosis; it also had significant positive correlation with the mean density of the plaques. We also found that total serum cholesterol, LDL cholesterol and serum triglycerides were significantly positively correlated with the calcium score and extent of atherosclerosis,where as HDL was significantly negatively correlated with calcium score and the extent of atherosclerosis |