الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Obesity, a global problem, is a multifactorial disorder. The factors are environmental, metabolic and genetic and their interaction with each other regulates the body weight. Imbalance in either of the factor may be responsible for weight gain (Nenna et al., 2007).
Leptin, a peptide hormone released from adipose tissue, is recognized to play an integral role in endocrine regulation of metabolism (Sandovel and Davis, 2003). Leptin regulates lipid and glucose metabolism by actions independent of its effects on appetite and body weight. It stimulates lipolysis, gluconeogenesis and glucose metabolism (Hollung et al., 2003).
This study was designed to investigate the changes that will occur in obesity and the effects of this changes on insulin , blood glucose and lipid metabolism.
Obesity is associated with insulin resistance and hyperinsulinemia. Both conditions increase the risk for coronary heart disease (Pyo”la”1979 and Welborn and Wearne 1979). Hyperinsulinemia seems to predict ischemic heart disease independent of other risk factors (Despre’s et al., 1996). The mechanism(s) underling the association between insulin resistance and obesity is not completely understood (Zhang et al.,1994 and Halaas et al., 1995).