الفهرس 
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Abstract
Diabetes mellitus, or simply diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the pancreas does not produce enough insulin, or because cells do not respond to the insulin that is produced.
(Shoback., 2011)
Complications of poorly managed diabetes mellitus may include cardiovascular disease, diabetic neuropathy, and diabetic retinopathy, among others. However, cardiovascular disease as well as neuropathy may have an autoimmune basis, as well.
Oxidative stress is a constant feature of uncontrolled diabetes in humans and animals (signgh .,et al 2001). Nonenzymatic antioxidants such as vitamin C and E are decreased in diabetes. (Tuzun ., et al 1999). Suggesting that oxidative stress in diabetes is, at least in part, due to impaired antioxidant system Additionally, reports from various laboratories on the activities of CAT , GSH , MDA have been controversial (Maritim., et al 2003).
Alloxan is a toxic glucose analogue, which selectively destroys insulin-producing cells in the pancreas (that is beta cells) when administered torodents and many other animal species . (Lenzen., et al 2008)
Arginine plays an important role in cell division, the healing of wounds, removing ammonia from the body, immune function, the release of hormones and Helps decrease blood pressure in clinical hypertensive subjects. (Tapiero., et al 2002)
Prpouse: To determine bioactivity of L-arginine on the progression of diabetes mellitus in diabetic rats to attenuate the progression of diabetic disorders in alloxan induced diabetic rats.
Method: 90 adult male healthy albino rats weighting (200 – 220) gm. were divided into 3 groups: Group (1) normal rats (30 rats). Group (2) (30 rats) served as positive control.Group (3) (30 rats) were given L-arginine in dose 200 mg/kg .
Then the second group and the third group were injected by alloxan monohydrate in dose 80 mg/kg in sterile (0.9%) Nacl intraperitoneally (I.P.) at once. After 72 hour of alloxan injection, blood samples were collected from the tail vien of rats and blood glucose was determined by one touch method.