الفهرس 
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Abstract
Persistent organic pollutants (dioxin and furan) are widely distributed and persistent in the environment. They are found in air and food as a result of fires and industrial wastes. These toxins have been found to affect different organs of human and animals. So, this study was performed to clarify their effects on the histological and immunohistochemical structure of the lung of adult male albino rats and the possibility of improvement after cessation of their administration. In addition, to evaluate the possible protective role of vitamin E supplementation.
For this purpose, forty eight adult male albino rats were utilized in this study. They were divided into four groups. Group I (control group), which subdivided into Ia, Ib, Ic subgroups and received tap water, corn oil and vitamin E respectively. Group II (dioxin and furan treated group) which were treated orally with a mixture of 100 ng/kg/day of 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) and 200 ng/kg/day of 2,3,4,7,8 Pentachloro-dibenzofuran (PeCDF) dissolved in (corn oil: acetone 99:1) for 13 weeks. Group III (recovery group) were treated with the same mixture of dioxin and furan and the same duration as in group II, then animals were sacrificed four weeks after cessation of treatment. In group IV (protected group), rats were treated with the same dose of dioxin and furan in concomitant with 50 mg/kg/day of vitamin E for the same periods.
The animals of all groups were anaesthetized by ether inhalation. Their thoracic cage were opened and the lungs were carefully dissected and processed for light and electron microscope examination. For light microscope examination, sections of 5 µm thick were obtained and stained with (H&E) stain to demonstrate the general structure of the lung, with Mallory’s trichrome to demonstrate collagen fibers, toluidin blue and.