الفهرس 
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Abstract
Preeclampsia is common medical complication of pregnancy, the incidence of preeclampsia is reported to be 8-10% of the pregnancies. It contributes significantly to maternal and fetal mortality and morbidity. Preeclampsia is a multi system disorder characterized by hypertension to the extent of 140/90mm Hg or more, proteinuria (≥300mg/day) and edema induced by pregnancy after 20thweek. Without intervention, preeclampsia progresses to eclampsia which is characterized by malignant hypertension and epileptiform convulsions requiring emergency caesarian section. The association of altered lipid profile in essential hypertension is well documented in early pregnancy, there is increased body fat accumulation associated with increased lipogenesis, while in late pregnancy, there is accelerated breakdown of fat depots which play an important role in fetal development. Early pregnancy dyslipidemia is associated with an increased risk of preeclampsia. Women with a history of preeclampsia have significant differences in lipid parameters and an increased susceptibility to lipoprotein oxidation when compared with women who had normal pregnancy. Therefore, simple measurement of serum lipid profile may be of good predictive value in preeclampsia. With this background in mind the present study was conducted to assess lipid profile in cases of preeclampsia and normal healthy pregnant women. We conducted in our study 251 pregnant women who attended the obstetric out-patient clinic for routine antenatal care examination at first trimester, with singleton pregnancy free of medical disorder, fasting blood samples were drawn from all cases, serum lipid were measured, we observed appearance of proteinuric hypertension in 26 cases which were have early pregnancy dyslipidemia and 174 remain normotensive with no serum lipid abnormality. Women who subsequently developed preeclampsia had higher concentrations of fasting serum total cholesterol, LDL-C and triglycerides than in those remaining normotensive group, HDL-C level was lower in preeclamptic cases than those remaining normotensive. So we concluded that early pregnancy dyslipidemia, particularly hypertriglyceridemia appears associated with increased risk of pre-eclampsia. Our current study showed that alterations in the triglycerides concentrations early in the pregnancy of women who later develop preeclampsia, may be of etiologic and pathophysiologic importance. Information from this study may contribute to the development and evaluation of behavioral and medical interventions aimed at reducing the occurrence of preeclampsia. On the other hand, preeclampsia appears to be a multi-etiological syndrome with heterogeneous biologic pathways. In summary, the findings reported in this study suggest that the women who develop preeclampsia had disturbed lipid profile due to abnormal lipid metabolism. Increased triglycerides, total cholesterol, LDL-Cholesterol levels and decreased HDL-Cholesterol, and high blood pressure may contribute as reasons for the development of preeclampsia. This association may be significant in understanding the pathological process of preeclampsia and may help in developing strategies for prevention and early diagnosis of preeclampsia.