الفهرس 
Peptic ulcerOnly 14 pages are availabe for public view
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Abstract
Peptic ulcer is in general a chronic and recurrent disease, defined as focal mucosal defect with inflammatory cell infiltration and coagulation necrosis extending through muscularis mucosa. Punica granatum has been used previously in folk medicine for the treatment of ulcer. Thus, the current study aimed to evaluate the anti-inflammatory and reparative activity of methanolic extracts of pomegranate peel (mesocarp and epicarp) on ethanol induced gastric ulcer compared with 3 drugs [Ranitidine (Ran), Omeprazole (Omz), and Sucralfate (Suc)]. This study was conducted on 90 male Wistar rats. Animals were divided into 9 groups each of 10 rats namely: Group 1; normal healthy rats used as negative control. Group 2; rats received 1 ml of 80% ethanol (positive control). Groups 3, 4, 5, 6, 7, 8 and 9; rats with experimental gastric ulcer treated with 250mg/kg, 500mg/kg of mesocarp, 250mg/kg, 500mg/kg of epicarp, Ran, Omz and Suc; respectively. Expression of inflammatory mediators (Cox-2, IL-1, IL-6 and TNF-α) and pro-angiogenic factors (VEGF and PDGF) were performed. Pomegranate peel extracts (PPEs) are found to possess anti-ulcer property. It was confirmed as anti-inflammatory agent by reduction of both gastric mucosal Cox-2 expression and plasma TNF-α level. In treated groups, the healing effect was approved by the elevation of PDGF level. Histopathological examination was confirmatory to the observed PPEs anti-ulcerogenic effect. PPEs-treated groups showed amelioration in signs of gastric ulcer which appeared similar to normal. A maximum ulcer healing effect was elicited in epicarp extract at 500mg/kg. In conclusion, PPEs have been considered as one of the anti-ulcer therapeutic strategies in gastric ulcer based on its anti-inflammatory and reparative activities.