الفهرس | Only 14 pages are availabe for public view |
Abstract Background: CKD patients are prone to episodes of hypoglycemia during hemodialysis, a condition that can cause severe health complications including dizziness, disorientation, slurred speech, and convulsions. Diabetes is the most common cause of kidney disease and managing diabetes in CKD patients can be complicated. Patients, who have diabetes and have CKD with reduced GFR, frequently have lower insulin requirements, reduced renal gluconeogenesis and prolonged half-life of antidiabetic drugs. Methods: 200 randomly selected patients with end – stage renal disease on regular hemodialysis were included in this study during the period form 1st of June 2011 till 30th of November 2011. Patients were fasting 2 hours before the session and 2 hours on the session, not receiving IV fluids or glucose. Random blood glucose readings were taken at zero time and after 2 hours on the hemodialysis session or with the development of symptomatic hypoglycemia. Data were analyzed in correlation with epidemiologic profiles, underlying etiologies and co-morbidities. Results: Hypertension and diabetes mellitus were underlying etiology of majority of cases. Less than one quarter of the patients experienced an episode of hypoglycemia during hemodialysis, with most of them aged between 40 – 60 years, having type 1 DM, cardiovascular disease comorbidity and lower HGB level, as compared to the non-hypoglycemic group. Conclusion: CKD patients on regular hemodialysis are at a significant risk for the development of hypoglycemia with or without the presence of diabetes, but the risk is greatest in patients with CKD and diabetes. Key words: End Stage Renal Disease, CKD, Hemodialysis, Diabetes Mellitus, Hypoglycemia. |