الفهرس 
Abstract
Bronchial asthmaOnly 14 pages are availabe for public view
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Abstract
A debate continues as to whether the association between C. pneumoniae
and asthma is causal or coincidental. While data on this association are rather extensive, no conclusions can yet be drawn about cause and effect .
The present study aimed to evaluate a possible relation between acute respiratory infection with Chlamydia pneumoniae and the current status of bronchial asthma. The study was enrolled during a period of 16 months from October 2012 to February 2014.
This study involved 75 subjects , divided into 50 patients have clinical evidence of different status of bronchial asthma and 25 age and sex matched healthy adult volunteers.
All subjects included in this study were subjected to :
• Full history taking including family history of asthma, atopy, smoking habits, diabetis mellitus and hypertension.
• Clinical examination: With emphasis on:Vital signs as respiratory rate, blood pressure and pulse and complete chest examination
• Radiological examination: It included plain chest X-ray (P-A and lateral views). to rule out other causes of chest diseases as pulmonary T.B and pneumonia.
• Pulmonary function tests: FEV1%, FVC%, FEV1/FVC Ratio and PEFR%.
• Routine laboratory investigations: CBC and Liver and kidney functions.
• Special Laboratory investigations: Serological detection of Chlamydia pneumoniae IgG Chlamydia pneumoniae IgM by microimmunofluorescence Assay (MIF) . The positive IgG samples was drawn after 2-4 weeks for detection of IgG titer increase.
In the present study, majority of patients were female (62%) and there were significant association between smoking, diabetes mellitus, hypertension , atopy and asthma, while no significance can be detected as regard family history.
Concerning hematological profile of the patient and control groups in this study, a significant increase (p<0.0001) in the Total Leukocyte Count, and the differential counts of eosinophil (p<0.003), and a significant decrease (p<0.01) in the lymphocyte count was detected.
Regarding our results of kidney function tests of bronchial asthma and control groups, there was significant decrease in BUN and significant increase of serum creatinine level in bronchial asthma group when compared with control group.
In this study ,according to pulmonary function tests ,there were highly significant difference between the mild to moderate (group I) ,severe (group II) patients group and control group and according to the degree of severity ,the decrease in pulmonary function will occur in inverse relationship.