الفهرس 
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Abstract
The study included 60 patients diagnosed SLE and 20 control, patients were recruited from rheumatology unit of internal medicine department in Assuit university hospital. Those patients were diagnosed using American college of rheumatology (ACR) revised criteria 1997, the disease activity in those patients were evaluated using Systemic lupus disease activity index (SLDAI). There age ranged from 14 and 40 years with a mean ±SD 27.62± 6.22 years, and the range of control group is between 19 and 34 years a mean ±SD 25.10± 5.08 years for the controls. Patients with clinically apparent infection, renal failure and liver cell failure were excluded.
All patients were subjected for complete medical history and through clinical examination.
To all patients the following investigations were performed:
A) Laboratory test: CBC, ESR, CRP, ANA, Anti DNA, urine analysis, 24 hours urinary proteins, liver function tests including liver enzymes prothrombin time and concentration, blood urea, creatinine.
B) Echocardiography and abdominal ultrasonography.
The results of this study showed that:
* 41 patients (68.3%) were considerd to have high disease activity according to SLDAI, while the remaining 19 patients (31.7%) were having moderat disease activity.
* ESR of the studied patients in the 1st hour ranged between 55 – 182 with a mean ± SD =101.97 ± 32.05 and for control group ranged between 10-41 and the mean ± SD is 19.85 ± 18.5 the p value is 0<0.001. While ESR of the studied patients in the 2nd hour ranged between 55 - 182=with a mean ± SD= 127.48 ± 29.30 and for control group the ESR ranged between 10-20, the is mean ± SD 7.5 ± 1.4 the p value is <0.001
* CRP of the studied patients ranged between 0.2-12 with a mean ±SD is 3.71 ± 2.78, while CRP of the control group ranged between 1-5 with a mean ±SD is 3.00 ± 1.41, p<0.001
* 24 urinary proteins of the studied patients ranged between 140-5770 with a mean ±SD is 1538.75 ± 1494.63, while 24 hours protein in urine of the control group ranged between 43-200 with a mean ±SD is 124.2 ± 45.94, (p<0.001).
* Haemoglobin level (gm/dl) was significantly lower in patients than control group (6.30 ± 2.59 vs 11.24 ± 2.41 p<0.001).
* Platelet count (103 /L) was significantly lower in SLE patients than control group (108.13 ± 49.05 vs 404.90 ± 81.72, p<0.001).
* WBC count (103 /L) was lower in SLE patients than control group (8.39±2.03 vs 11.11±1.22) but not significant, p<0.05.
* Blood urea in patients was ranging from 2 mmol/l-45 mmol/l, while blood urea in control ranging from 2 -25 mmol/l with p-value 0.873.
* Serum creatinine in patients was ranging from 19-199 mg/dl with mean ±SD87.42 ±43.73, while serum creatinine in control group was ranging from 16-90with mean ±SD56.30 ±20.11with p-value<0.003.
* The result of the study shows that no significant correlation between CRP and SLE disease activity using SLDAI (p=0.396 and r=-0.111).
* There is positive significant correlation between ESR1 and SLE disease activity (p=0.001 and r=0.411).
* There is positive significant correlation between ESR2 and SLE disease activity (p=0.002 and r=-0.388).
* There is negative significant correlation between C3 and C4 mg/dl and SLE disease activity (p=0.000, p=0.000 and r=-0.536, r=-0.594) respectively.