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Abstract THE PRIMARY function of the heart is to serve as the muscular pump for the circulatory system. Recent ev1dence has proven that the heart is also an endocrine organ (Palluk et al .. 1985). Atrial peptides. collectively known as atrial natriuretic hormone (ANH), are released from secretory granules located in atrial, but not ventricular. myocytes and have been shown to induce diuresis, natriuresis, and vasorelaxation in animals and man. Atrial distension appears to be the predominant $timulus that triggers release of ANH in rats (Bates et al., 1986). Bergman et al., 1n (1988) reported that malnutrit1on caused a stunted growth and produced generalized tissue wasting, particularly a severe loss of muscle tissue and protein, which almost certainly included the heart muscle. Various cardiovascular abnormalities have also been documented. including low cardiac output. cardiac failure (reduced cardiac size), and sudden unexpected death. This study aims at studying the ANP in malnourished children (KWO and M. KWO), to find out if it could be adverselY affec.ted by their state of malnutrition. and its implication on salt and wat·er retention. |