الفهرس 
HISTORICAL REVIEWOnly 14 pages are availabe for public view
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Abstract
HISTORICAL REVIEW
The Llisorder termed mixed connective tissue
o!iscase refers to a syndrome first described by
c3llarp et al (1971), in which the common finding was
L!1c presence of high concentration of serum antibody
which react with saline extractable nuclear antigen.
The clinical characteristics of the patients with
mixed connective tissue disease include a combination
of features similar to those of systemic lupus erythematosus,
scleroderma and polymyositis, and it is
characterized by an excellent response to corticosteroid
therapy and a favourable prognosis. (Sharp et al, 1972)
Klinge in 1933 was the first one who proposed
the idea of systemic involvement of the entire connective
tissues of the human body in rl1eumatic arthritis
;we! other rheumatic diseases.
ln subsequent years there was intensive studies
abouL the collagen diseases. Hargraves et al, (1948)
published their discovery of the LE cell phenomenon
and llench et al in (1949) published their work on the
treatment of rheumatoid arthritis by cortisone.