الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The subject of this thesis is the preparation and
characterization of some novel diaryldithiophene and
mono hetero and/or dithiophene Derivatives were
designed, synthesized under stille coupling reaction
conditions and evaluated for their antitumor activities on
3 different cell lines; Breast, Liver and Lung Cancer.
Chapter One ”Introduction” :
This includes detailed survey of some
organometallic complexes and gives a general
introduction survey, review and new scientific
background of the basic principle theory of palladiumcatalyzed,
cross-coupling and oxidative addition
reactions including examples for the synthesis of some
organometallic complexes related to our work.
Chapter Two ”Results and Discussion” :
This chapter deals with a detailed study for the
synthesis, characterization and describes the strategy of
the methods that can be applied to give products in pure
form, resulting in the synthesis of a class of compounds
by stille coupling reaction process, using different
reagents.
It includes as well investigating the synthesis of the
following compounds
5,5’-di(thiophen-2-yl)biphenyl-2,2’-diol (46)
2,2’-bis-benzyloxy-5,5’-di(thiophen-2-yl)-biphenyl
(48)
2,5-di(thiophen-2-yl)pyridine (50)
5-(thiophen-2-yl)pyrimidine-2,4-(1H, 3H)-dione (52)
2-(thiophen-2-yl)quinoline-3- carbaldehyde (54)
Biological evaluation and docking study of the
prepared compounds
Novel diaryldithiophene and mono hetero and/or
dithiophene derivatives (46,48,50,52,54) were
evaluated for their antitumor activities in 3
different cell line such as, Breast (MCF7), Liver
(HEPG2) and Lung Cancer (A549). All
Compounds exhibited highly potent cytotoxic
activity with IC50 values in 0.042 – 4.09 μM
range. Also molecular docking study was carried
out using complex (H10V) as template to predict
the binding affinity of the target compounds to the
receptor.
Chapter Three ”Experimental” :
This incudes detailed experimental work and
figures for all the measured data and charts of IR, MS,
1H-NMR for all the products.