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Abstract Although major advances have been made in both obstetric care of the high-risk patient and in neonatal care, prematurity and its consequences remain the major contributor to perinatal mortality, the identification of maternal or obstetric risk factors associated with preterm delivery has enhanced our ability to provide special obstetric care to gravid as at increased risk (Gravett, 1984). Significant risk factors of a preterm delivery included 1 ow socioeconomic status, inadequate weight gain duri ngs the pregnancy; a previous preterm delivery; a history of infertility problems; an induced abortion terminating the previous pregnancy; vaginal spotting or light bleeding during the pregnancy; antepartum hemarrhage and abnormal placental implantation; lack of leisuretime physical activities during the pregnancy; alcohol consumption prior to the third trimester of pregnancy {Berkowitz, 1981). There is a pressing need for an improved method of diagnosis. If some biochemical means were available to diagnose preterm labor, the short-term use of tocolytic therapy would be indicated in questionable cases of preterm labor, until such time that improved methods of diagnosis are available. It would seem preferable to err on the side of overdiagnosis, particularly in very early preterm labor where neonatal morbidity and mortality are excessively high (Creasy, 198 |