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Abstract INTRODUCTION Fami 1 ia 1 .Mediterranean Fever IF. M. F) an inherited systemic inflammatory disease of unknown etiology characterised by odic acute attacks of fever and serositis (Tovi et al., 1985). F.M.F. can be considered uncommon disease in Egypt (Hassan et al., 1972). The disease is most frequently encountered in ethnic groups of Mediterranean ancestry particularly Jews {Siegal, 19 4 5), Armenians, Arabs (Reimann et al. , 19 54) and Turks (Ozer et al., 1971). The name ”Mediterranean” has been coined to the disease since 1955 by Sohar (Sohar et al., 19691 because of the co~~on incidence of F.M.P. in the countries of the Mediterranean basin. Extensive work has been done to discover the etiology of F.M.F. Such investigations included routine haematological, bioichemical and bacteriological tests. Other investigation related to lipidmetabolism, amino·acid studies in blood and urine [(Hamed, 1972), (Manialawi et al., 1974)] and porphyrin studies have been carried out. Certain hormonal studies including etiocholanolone in blood and urine were performed (Manialawi, 1973). Platelet function and haemostatic mechanisms in cases of F. M.P. have been |