الفهرس 
Nephrotic syndromeOnly 14 pages are availabe for public view
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Abstract
Nephrotic syndrome is characterized by massive proteinuria (urinary total protein >1 g/m2/ day or urinary spot protein creatinine ratio of >200 mg/mmol), hypoalbuminemia (serum albumin ≤2.5 g/dL), edema, and hypercholesterolemia (serum cholesterol ≥200 mg/ dL). The clinical outcome of the disease depends upon the age at presentation, histological changes, absence of hematuria, hypertension, impaired renal function, and responsiveness to steroid therapy.
Disease associated with T-cell dysfunction and secondary disturbance of B-cell that leads to changes in levels of immunoglobulins leading to high level of IgM and a low level of IgG. Therefore the estimation of IgG and IgM levels and their ratio as well as correlation of these values with clinical responsiveness to steroid therapy, relapse, and dependency is important to monitor.
The present study was carried out on 50children divided into 2 groups: Group Ι: Included 25 children with nephrotic syndrome attended to Nephrology Unit of Pediatric Department of Menoufiya University Hospital from October 2011 to January 2013. Their ages ranged from 1-15 years (mean= 7.1 years), 15(60%) were boys while 10(40%) were girls.All patients were in the active stage of the disease. Group ΙΙ: Included 25 apparently healthy children enrolled as control group. Their ages ranged from 1-15 years (mean=6.9 years), 14(56%) were boys while 11(44%) were girls.