الفهرس | Only 14 pages are availabe for public view |
Abstract SUMMARY & Conclusion Neonatal jaundice affects 60% of full term infants and 80% of preterm infants in the first 3 days after birth. Jaundice should be considered non physiologic or pathologic if it occurs less than 24 hours after birth, if bilirubin levels rise at rate of greater than 5 mg/dl. Early diagnosis dramatically improves the chance of intact survival; innovations in the surgical management have improved the prognosis. Fortunately, a series of blood studies can indicate a diagnosis of infection, hematologic problems, metabolic diseases or genetic disorders. Many diagnostic methods are used to differentiate between surgical and non surgical cases of jaundice including, ultrasound, HIDA scan, magnetic resonance cholangiopancreaticography (MRCP), duodenal aspiration analysis, liver biopsy and laparoscopic exploration and cholangiography. In this work we focused on the etiology, pathology, diagnostic methods, surgical management and its complications of the commonest surgical causes of neonatal jaundice which include biliary atresia, choledochal cyst, sudden perforation bile duct and cholelithiasis. Biliary atresia is an idiopathic inflammatory process, involving the bile ducts resulting in obstruction of the biliary tract, chronic cholestasis and progressive fibrosis and eventually leads to biliary cirrhosis; it is the most common cause of liver transplantation in children so the early diagnosis is essential for effective surgical treatment. Choledochal cyst is a rare congenital dilatation of the common bile duct, often associated with dilatation of intrahepatic ducts, it occurs in any age, two thirds of cysts are present before age of 10 years, complete excision of the cyst and biliary bypass have become the treatment of choice. Sudden perforation of the bile duct is a rare but important cause of jaundice in infancy, it should be suspected in an infant who develops progressive ascites and abdominal distension, irritability and fluctuating mild jaundice, but laparotomy is ultimately necessary for definitive diagnosis and treatment. Gall bladder calculi are relatively uncommon in children, but it seems to be increasing, the hemolytic and non hemolytic cholelithiasis are focused on in this wok as well as the management of gall bladder stones. Over the last 25 years, orthotopic liver transplantation has evolved from an experimental measure to become the standard of care in the salvage of child with end stage liver disease, the technical development, care improvement and new immunosuppressive agent have markedly altered the management of children who require liver transplantation, as a result, the outcome of these children has improved significantly. |