الفهرس | Only 14 pages are availabe for public view |
Abstract This study included 80 subjects divided into four groups : Group I: (rheumatoid group): Included 20 rheumatoid arthritis patients associated with anemia. Group II: (chronic liver disease group): Included 20 chronic liver disease patients associated with anemia . Group III: (thalassemia group): Included 20 patients with thalassemia. Group IV: (control group): Included 20 apparently healthy subjects (as control group). All patients and controls were submitted to the following investigations: Lab. Investigations •Routine investigations: 1-Complete blood count (CBC) . 2-Renal function tests (blood urea, serum creatinine). 3-Liver function tests (ALT, AST, serum albumin and total protein). 4-HB Electrophoresis. 5-Serum iron and serum ferritin assay. 6-Erythrocytes sedimentation rate (ESR). 7-C- reactive protein. 8-Rheumatoid factor. •Special investigations 1-Hepcidin level assay by enzyme immunoassay (EIA). Results of different groups were compared with each other and were summarized as follows: There were statistically significant increase in hepcidin levels in group I, II, III when compared to control group (P= 0.002, 0.001, <0.001) respectively. Also, hepcidin levels were significantly higher in group III compared to group I and II (P = <0.001, <0.001) respectively. While no significant difference was found between group I and II (P = 0.665). There was significant strong positive correlation between hepcidin level and serum ferritin level in all patients groups (P = <0.001), and significant strong positive correlation between hepcidin level and serum iron level (P = <0.001), while there was significant negative correlation between hepcidin level and Hb level (P = <0.001). |