الفهرس 
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Abstract
Objective : The aim of the present research was to compare the osteoconductivity of both Bio-Gen⍟ and Nano Bone⍟⍟ after implantation in experimental osseous defects in rabbit tibia.
Materials and methods: Thirty adult male New Zealand white rabbits were used in the study. Two holes, 1 cm apart, were created in each tibia reaching the bone marrow. The lower hole of the right tibia was packed with Bio-gen material, while the upper hole was left empty to serve as control. In the left tibia Nano Bone was packed in the lower hole while the upper hole was left empty to serve as control.
Results: histological analysis revealed a more accelerated pattern of bone healing in the graft augmented bone defects as compared to the control defects. Furthermore, the Nano-bone augmented defect showed a more advanced pattern of bone healing than the Bio-Gen augmented bone defects Histomorphometric analysis showed the highest bone area percentage in the Nano Bone defect, followed by the Bio-Gen defect and the control defect. Furthermore, the highest bone mineral density was recorded in the Nano Bone defect followed by the Bio-gen and the control defects.
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Conclusion: the defect augmented with Nano Bone was rapidly obliterated with newly formed more mature, more compact bone than both the empty control bone defect and the Bio-Gen loaded defect. It could be hypothesized that Nano Bone owing to its biomimetic and early bioresorbable properties, is integrated into the host’s bone tissue at early stage allowing an enhanced bone healing process.