الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
The aim of the study was to compare the bone healing potential of NanoBone (a synthetic bone graft material produced by nano-technology) versus MinerOss (a freeze dried bone allograft) in a rabbit tibial defect model. Materials and methods: Thirty adult male New Zealand white rabbits were used in this study. Two holes 1 cm apart 3.5 mm in diameter were created in each tibia reaching the bone marrow. The NanoBone was packed in the upper holes of the right side tibiae while the MinerOss was packed in the upper holes of the left side tibiae. The lower holes of the right and left tibiae were left untreated without any grafting material and acted as controls. The rabbits were randomly assigned into three groups I, II & III (10 rabbits each) according to the date of sacrifice 2, 4 and 6 weeks respectively. The specimens were then examined histologically, histomorphometrically and densitometrically using Dual Energy X-ray Absorptiometry (DEXA) scan. Results: MinerOss and NanoBone accelerated bone healing when compared to control empty holes. Histomorphometric analysis revealed an increase in the area bone percentage in the treated holes either with MinerOss or NanoBone as compared to control holes. Densitometrically, the highest mean bone area % was recorded in the MinerOss treated holes in all the experimental groups followed by NanoBone then control group. Conclusions: It could be concluded that the MinerOss and NanoBone treated holes showed enhanced pattern of bone regeneration, as compared to the control empty holes confirming their osteogenic and osteoconductive role.