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Abstract Kidney dysfunction commonly develops in patients with established liver disease, in the most severe form, this kidney dysfunction is called the hepatorenal syndrome. The pathogenesis of HRS involves the development of hyperdynamic circulation with lowering of the renal perfusion pressure. Renal hemodynamic changes begin early in the course of liver disease related functional kidney failure. The hallmark change is intense intra-renal vasoconstriction associated with reduced renal blood flow and elevated renal arterial vascular resistance. This study was conduced to evaluate the renal hemodynamic changes by renal duplex Doppler ultrasound as predictors of kidney dysfunction and HRS in different stages of liver cirrhosis. The study was carried out on 50 patients and 5 healthy control subjects. The patients were divided into 5 groups Group I: 5 normal control subjects. Group II: 15 patients with liver cirrhosis without ascites (compensated cirrhosis). |