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Abstract This study was designedto determine the difference inresistin levels intheserum ofpatientswithsystemiclupuserythematosus(SLE)and rheumatoid arthritis (RA) compared to a control group of apparent healthy persons. The aim extends to examine the relationship and possibleassociationsbetweenthelevelsofresistinanddifferentmarkers of disease activity, inflammation, renalfunction, lipidsand bone mineral densityinpatientswithSLEandRA,in ordertoassessthevalueof resistinasaspecificmarkerofinflammationinpatientswithSLEand RA. Thisstudyincludedthreegroups: Group (I): Included30patientssufferingfrom SLEdefinedaccordingto the updatedAmericanCollegeofRheumatology(ACR)revisedcriteriafor the classification of systemic lupus erythematosus (SLE) (Hochberg, 1997). They wereallfemales(100%)whoseagesrangedbetween19-62 years(meanof40.36±SD 10.55years) and disease durationranging between 1-25years (meanof9.73± SD6.78years).ThemeanBMIof thisgroupwas32.055±SD1.07kg/m2witharange from20.96-40kg/m2. Group (II): Included 30 patients suffering from RA defined according to the AmericanCollegeofRheumatology(ACR)revisedcriteria(Arnettetal.,1988). Theywereallfemales(100%)whoseagesrangedbetween20to 60 yearswith(meanof40.24±10.41years)anddiseasedurationranging between6months-16years(meanof6.18±SD3.7years).Themean BMIofthisgroupwas29.48±SD1.11kg/m2 witharangefrom22.3- 38.46 kg/m2. Group (III) A controlgroupincluding30apparenthealthyvolunteersmatched forageandsexwithother groups,they wereallfemales(100%).Their agesrangedbetween21-57years(mean38.07± SD11.12years). The meanBMIinthisgroupwas30.17±SD1.23kg/m2 witharangefrom 23.47-39.87kg/m2. Allpatientsweresubjectedtofullhistory taking,fulldetailed clinicalexamination,laboratory assessment(ESR,CRP,renalfunction, urineexamination, lipidprofile, RF, ANA, anti-dsDNA, ACPA, C3and C4),X-ray both handsforRA patients,DEXAscanforbothSLEandRA patients,assessmentofdiseaseactivity accordingtoSLEDAIforSLE patientsandaccordingtoDAS28scoreforRApatient’sandassessment of radiologicaldamage for RApatientsusingLarsenscore. Serum samplesfromallpatientsandcontrolsaretestedforresistinlevels. BMI wascalculatedfor patientsandcontrol. Patientswiththefollowingconditions were excludedfromthe study:- 1.Pre existingdiseases causingnephritis, 2.Evidenceofmalignancy, 3.Concurrent infection, 4.Diabetesinpatientsandcontrol. Theresultsofthisstudywereasfollows Bystudyingthe resistinlevelsinsera of SLE,RAandcontrolitwas foundthat: ♦ThemeanresistinlevelsinseraofSLEpatientswas2.866ng/mlwith range 0.125- 12.52ng/ml. ♦WhilethemeanresistinlevelsinseraofRApatientswas3.002ng/ml withrange 0.886- 8.964ng/ml ♦Inthecontrolgroupthemeanlevelsofserumresistinwas2.144ng/ml withrange 0.134-7.767ng/ml. Althougthe meanof serumresistinlevelsinSLE(2.866ng/ml) is greaterthancontrol(2.14ng/ml).Itwasinsignificant(p=.233). The meanof serumlevelsof resistininRAis(3.002ng/ml) was greaterthancontrol(2.14ng/ml).ButIt wasinsignificant(p=.070) butclose tobe significant. There wasnosignificantdifferencebetweenserumlevelsof resistinbetweenSLEandRAparients(p=0.098). The comparisonbetweenthe resistinlevelsof the previousthree groupswasnotstatisticallysignificantwhere p˃0.05. AsregardSLE: The effectof diseasedurationonserumresistinlevelsinSLEwere insignificantcorrelations(p>0.05). Alllaboratoryparametershadinsignificantcorrelationswithserum resistinlevelsexcepttheplateletsthathadaninverse significant correlation(p=0.022). There isinsignificantcorrelationbetween serumlevelsof resistinandSLEDAI (p=0.180). Nosignificantcorrelationwasfoundbetweendailydoseofsteroid, antimalarial,azathioprine orcyclophosphamideandserum resistin levels. TheeffectofT-scoreHip,T-scoreVertebraeandVitaminDon serum resistinlevelsinSLEwereinsignificantcorrelations (p>0.05). AsregardRA: The effectof diseasedurationonserumresistinlevelsinRA were insignificantcorrelations(p>0.05). Alllaboratoryparametershadinsignificantcorrelationswithserum resistinlevels(p>0.05). There was no significant correlation between weekly dose of methotrexate,daily dose ofanti-malarialandadalimumabtherapy andserumResistin. The effectof T-scoreHip,T-score Vertebrae andVitaminDon serumresistinlevelsinRAwere insignificantcorrelations (p>0.05). Thereisinsignificantcorrelationbetweenserumlevelsofresistin andDAS 28(p=0.207). No significant correlation between serumlevels of resistin and Larsenscore (p=0.735). |