الفهرس 
HypertensionOnly 14 pages are availabe for public view
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Abstract
Hypertension is one of the most important public health challenges
worldwide because of its high frequency and concomitant risks of
cardiovascular, cerebrovascular, renal failure and other complications.
Essential hypertension is the form of hypertension that by
definition has no identifiable cause and is the most common type of
hypertension. It tends to be familial and is likely to be the consequence of
an interaction between environmental and genetic factors
Protein tyrosine phosphatase1B (PTP1B) is the prototypic member
of the PTP family (which is a large family of enzymes expressed in all
eukaryotes that catalyze the hydrolysis of phosphotyrosine in proteins to
tyrosine and inorganic phosphate). PTP1B is known as a negative
regulator of leptin and insulin signalling, two pathways important in
energy homeostasis. It also plays a key role in many signalling networks
in human disorders particularly in diabetes, obesity, hypertension and
cancer.
The aim of this study was to evaluate the possible role of
g54281T>A polymorphism of PTP-1B gene in the development of
hypertension and dyslipidemia.
This study included 57 subjects 35 males and 22 females, their
ages ranged between 46-82 years. The studied subjects were divided into
two groups, group I included 37 hypertensive patients, (23 males and 14
females) with age ranged between 46-82 years, group II included 20
apparently healthy age and gender matched subjects as a control group
(12 males, 8 females), their age ranged between 49- 81 years.
All subjects were submitted to the followings: History taking,
clinical examination, blood pressure assessment and laboratory
Summary
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investigations. These included: FBS, total lipid profile (TC, TG, HDL-C
and LDL-C), BUN, creatinine and determination of PTP1B genotypes by
PCR–RFLP. The results of this study revealed that:
The studied groups were well matched as regard age and gender.
As regard weight and BMI, group I showed higher statistically
significant differences compared with group II; meanwhile, no
statistically significant difference in height between both groups.
Regarding blood pressure, group I showed higher statistically
significant differences in the mean SBP & DBP comparing with group
II.
There was statistically significant difference in the mean FBS between
group I and group II for favour of group I. Meanwhile, there were no
statistically significant differences in the mean of BUN and creatinine
between both groups.
Regarding lipid profile, the level of TG was significantly higher in
group I when compared with group II. Meanwhile there were no
statistically significant differences in TC, HDL-C and LDL-C between
group I and group II.
As regard genotype distribution, TT genotype was higher in group II
comparing with group I. Meanwhile, AA & TA genotypes were higher
in group I than group II. However, these differences did not reach a
statistical significance.
Regarding allele frequency, T allele was more represented in group II;
while A allele was higher in group I, showing statistically significant
differences in the distribution of both alleles (T and A) between group
I and group II.
Summary
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The obtained results in this study showed that TA genotype is more
risky for hypertension 1.75 times than TT, while AA genotype is more
risky 9.63 times than TT. Also, A allele is more risky 3.59 times than
T allele.
There was a statistical significant difference between genotypes of
group I regarding BMI (AA was statistically higher than TT). But,
there was no statistical significant difference between different
genotypes as regard weight and height.
There were no statistically significant differences between different
genotypes of group I as regard SBP, DBP, FBS, BUN and creatinine.
Regarding lipid profile between different genotypes of group I, the
obtained results showed that TG level in AA & TA genotypes were
statistically higher than TT genotype. Meanwhile, there was no
statistical significant difference between TA & AA genotypes. On the
other hand, there were no statistical significant differences between
different genotypes as regard