الفهرس 
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Abstract
Over the years, thalidomide has been used in the treatment of various hematologic malignancies, solid tumors such as colon, brain and a variety of inflammatory and autoimmune diseases. Phthalimide moiety is one of the thalidomide metabolites and might be the effective part of thalidomide toward many diseases. Prior studies have identified that the introduction of an ester function group into the core structure of some plant-derived anticancer agents improved their activity against the usual cell line.In the present work, a series of thalidomide and phthalimide ester analogues was synthesized efficiently and the antitumor activity of all the synthesized compounds were evaluated against human breast adenocarcinoma (MCF7) and hepatocarcinoma (HepG2) cell lines as well as their effect on the immune cells using in vitro assays were evaluated. Meanwhile, the estimation for all the synthesized compounds toward the binding affinity to VEGFR was discussed.N-Chloromethylthalidomide 247, N-chloromethyl and N-(2bromoethyl)phthalimide 248a,b derivatives were allowed to react with various biologically important carboxylic acids 249a-d in the presence of triethylamine (TEA) and catalytic amount of 4-dimethylaminopyridine (DMAP) stirring at 50-60ºC in DMF to afford 250a-d and 252a-d and stirring at room temperature in CH3CN for 48h to afford 251a-d in good to excellent yields (Scheme A & B).On the other hand, dithiocarbamates are widely used in medicinal chemistry and have found application in the treatment of cancer. Recently, dithiocarbamic acid esters have also attracted great attention due to their cancer chemopreventive and anticancer activity. Thus in the present work, it was interesting also to synthesize new derivatives of thalidomide and phthalimide dithiocarbamate derivatives and evaluation of their antitumor activity.