الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
This study aimed to : Acute myeloid leukemia (AML) is a clonal hematopoietic disorder characterized by clonal accumulation and expansion of immature myeloid cells within the bone marrow.CXCR4 is commonly expressed by a variety of leukemia cells, both lymphoid and myeloid. The CXCL12/CXCR4 interaction has been shown to be critical in the retention of both HSCs and leukemia cells in the bone marrow as exposure to CXCL12 leads to increased affinity of CXCR4 positive blasts to niches in the bone marrow microenvironment. This retention plays an important role in protecting AML cells in the marrow niche, especially during intensive chemotherapy. In addition, CXCL12-induced migration may play a role in the development of extramedullary leukemia. The ability of blasts to exit from the bone marrow microenvironment, circulate in the peripheral blood, and anchor in extramedullary locations might depend on the CXCL12 genotype. The aim of this work was to study the expression of CXCR4 by flow cytometry and the CXCL12 gene polymorphism by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay and correlate them with the clinical characteristics, prognosis and patient outcome.