الفهرس 
cover englshOnly 14 pages are availabe for public view
 |  | from | 181 |  |  |
| | | from | 181 | | |
Abstract
Lymphoproliferative malignancies with different presentations, behavior,pathology, cellular origin, response to treatment and prognosis Armitage, 1993).Malignant lymphomas are important oncologic problems in Egypt ranking the third among cancers. Malignant lymphomas in Egyptian patients present with special features that are distinctly different from those reported in the western literature. Thus, in Egypt diffuse aggressive lymphomas predominate and constitute 87% of cases in adults and 100% in children. The patients present at advanced stages with 85% of cases having stages III and IV. This and predominance of high grade tumors is possibly related to the exposure of Egyptian population at a younger age< to various bacterial, parasitic and viral infections which result in sustained stimulation of the lymphoid system. Immunological deficiency as a result of malnutrition may also be involved (El Bolkainy, 1998).Many clinical features have influenced the response to treatment of NHLs such as age, sex, stage of disease, size of the tumor, B- symptoms,serum LDH level, performances status and number of extra nodal sites(Shipp, 1994).Survival data were analysed for adult NHL patients treated at the department of Medical Oncology, NCI during the years 1975 –1986. The 10 years survival rate was 34.5% for COP-therapy and 22.7 % for CHOP therapy.