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Abstract Atmospheric changes such as depletion of ozone layer in the stratosphere are believed to lead to rises the level of ultraviolet radiation on the earth. In general, there are a number of body components that absorb ultraviolet radiation and may induce photochemical damage to the tissue. The most common are chromophores, nucleic acid and proteins including various types of enzymes. All these factors lead to opacity of the normal crystallin lens that produces an impairment of vision and associated with cataract formation. This study aimed to investigate the damaging effect of total and fractionated doses of ultraviolet B (UVB) radiation on the eye lens and the effect of melatonin against oxidative stress in UVB radiationinduced cataract development. Twenty-five New Zealand male rabbits weighing 1.5-2 kg were used in this study and divided into five groups (five rabbits each). Group I. Rabbits kept as control without any treatment. Group II. Rabbits received a total dose of 3.12 J/cm2 UVB and they were left for one week. Group III. Rabbits injected intraperitoneal with melatonin (4mg/kg) daily for one week before exposure then they received a total dose of 3.12 J/cm2 UVB and following the exposure they again injected intraperitoneal with melatonin daily for one week. |