الفهرس 
HyperthermiaOnly 14 pages are availabe for public view
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Abstract
Breast cancer is usually treated with surgery, radiotherapy and chemotherapy. Fever-range hyperthermia treatments (HT) enhance the effect of radiotherapy and chemotherapy in terms of local tumor control and survival rates. Electromagnetic (EM) radiation is commonly used; however there is an increasing interest for using ultrasound (US) due to the larger penetration depth and better focusing capabilities. An adequate applicator for fever-range HT treatment of tumors in the entire intact breast region is not yet available. The purpose of this work is to describe the theoretical design and characterization of an ultrasound cylindrical phased-array applicator. The US applicator is used to compute heating profiles in breast tumors and the results are obtained.
In this thesis, breast models are constructed from human data that is obtained from Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) scans. Design parameters such as frequency, number of physical elements, width of element, kerf (spacing between element), and display angle of ultrasound transducer are optimized to obtain the smallest possible focus. The field ii program will be used for simulating ultrasound transducer fields and ultrasound imaging using linear acoustics. The k-Wave toolbox is developed to show how the nonlinear beam pattern from an ultrasound transducer can be modeled.