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Abstract Drug residues of oxytetracycline L.A. in rabbit (kidneys, liver and breast muscle) was determined using high performance liquid chromatography (HPLC) after single intramuscular administration of drug at a dosage of 20 mg/kg b.wt. from this study, we need to know the withdrawal time of oxytetracycline LA (Alamycin LA®) from (kidneys, liver and breast muscle) of rabbit after single intramuscular administration of drug at a dosage of 20 mg/kg b.wt and therefore when rabbitsʹ organs (kidneys, liver, breast muscle) become safe for human consumption. Experimental design Thirty clinically healthy Newzeland rabbits weighting 2-2.5 kg and 2 months of age were obtained from Farm of faculty of Veterinary Medicine, Zagazig University. The rabbits were housed in batteries in post graduate research laboratory in Faculty of Veterinary Medicine, Zagazig University and fed balanced ration with free access to water. Rabbits were injected with oxytetracycline LA (Alamycin LA® ) by a dosage of (20 mg/kg b.wt) by deep I/M and slaughtered at 1st ,3rd ,5th , 7th ,14th ,21st ,28th ,30th ,32nd days post injection (3 rabbits at each) and 3 rabbits kept as a control. |