الفهرس 
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Abstract
Neonatal sepsis remains one of the most important causes of mortality despite considerable programs in hygiene, introduction of new antimicrobial agents, and advanced measures for early diagnosis and treatment.
This study aimed at measuring NO levels in septic and control groups for evaluation of it’s role in diagnosis of sepsis.
This study was done on 50 neonates devided into two groups:
- Group A formed of 30 neonates sufferjng from sepsis and present in the NICU, and devided into two subgroups (15 preterm and 15 full term).
- Group B formed of 20 healthy neonates taken randomly from outpatient clinic of pediatric hospital who attended for follow up.
All neonates were subjected to:
- Perinatal, natal and postnatal history taking:
We recorded the sex, body weight, perinatal, natal and postnatal data as a risk factor of neonatal sepsis.
- Clinical examination:
We performed laboratory tests as following:
*Complete Blood Picture:
Which revealed that sepsis is accompanied by thrompocytopenia but in WBCs there is no specific difference between groups which may need more specific investigations eg. differential leukocytosis.
*Detection of CRP:
Revealed rising in CRP levels in the septic groups in comparison to healthy groups.
*Blood culture:
Proved that bacteria is the most common cause of neonatal sepsis and most common organisms are Klebsiella, Pseudomonas, Ecoli and staphylococcus aureus.
*Determination of NO level:
- We measured serum NO in all groups.
- Then we compared these results in each group which revealed significant increase in the levels of NO in the septic groups in comparison to control groups.