الفهرس 
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Abstract
Summary
Metabolic syndrome is a condition which is considered to promote atherosclerosis, and increases the risk of cardiovascular events (Scott et al., 2003). The NCEP-ATPIII definition includes the presence of three or more of the following five criteria: central obesity (WC ≥90 cm for males, ≥80 cm for females), elevated BP (systolic BP ≥130mmHg or diastolic BP ≥85 mmHg), elevated TG (≥150 mg/dL), reduced HDL cholesterol (<40 mg/dL for males, <50 mg/dL for females), and elevated FBG (≥110 mg/dL). A previous diagnosis of type 2 diabetes mellitus is considered to be evidence of an elevated FBG. Each abnormality promotes atherosclerosis independently, but when clustered together, these metabolic disorders are increasingly atherogenic and enhance the risk of cardiovascular morbidity and mortality (Ford et al., 2004).
MetS is a term used to define a patient who presents with three or more of the five carefully defined risk factors (Grundy et al.,2004).
Coronary artery disease has been accepted as a major source of Cardiovascular morbidity and mortality in adults (Braunwald et al., 2009). There have been numerous trials in order to modify risk profiles for this group of patients. Our study aimed to search for the correlation between MetS and coronary artery disease.
The aim of this study was to study the correlation between metabolic syndrome and coronary artery disease in Egyptian patients undergoing coronary angiography for known coronary artery disease. Our study consists of 125 consecutive patients who were doing their first elective coronary angiogram for the evaluation of coronary artery disease in the cath lab unit at the National Heart Institute (N.H.I), they were diagnosed to have IHD due to previous history of hospital admission either with STEMI or NSTE ACS were divided into two groups of patients (Group I & Group II) group I (75consecutive patients) include patients who fulfilled the diagnosis of metabolic syndrome according to National cholesterol education program/ Adult treatment panel III(NCEP/ATPIII) definition, group II( 50consecutive patients) included patients who didn’t have metabolic syndrome to detect which component of metabolic syndrome is more predictor of severity of coronary artery insufficiency.
In our study all patients in group I (MetS group) had low HDL & high TG and large waist circumference. 51 patients had HTN& 50 patients had DM to compare which of them had more predictor of CAD severity.
In our study there was no statistically significant difference between the two groups as regards Age & sex & smoking status and family history of CAD.
In our study the mean BMI was higher in Group I than the mean BMI in Group II with p value 0.016. This finding came in agreement with the study of Yoon et al., 2011 as the BMI was greater in metabolic syndrome patients than non-metabolic syndrome with p value < 0.001
In our study the comparison the mean GS in Males of Group I (MetS) was 47.1 ± 31.66, while in females in the same group was 48.3 ±43.7 with p value 0.4974. Although in Group II the mean GS in males was 18.65±5.7.while in Females was 18.26±6.9 with p value 0.8642. While when we compared the males in Group I& Group II the mean GS was higher in Group I than Group II with p value 0.0006 also the mean GS in females was higher in Group I than Group II with p value < .00001.
In our study there was positive correlation between the numbers of components used to diagnose metabolic syndrome were directly proportional to the mean Gensini Score (GS) of these patients as follow: the mean GS in patients with 3 criteria was 37.1±22.7, the mean GS in patients with 4 criteria was 47.2±35.6 and the mean GS inpatients with 5 criteria was 56.7±42.6 with p value 0.045.
In our study we studied the incidence of multi vessels which was found to be more common in MetS patients than non-MetS patients while the incidence of single vessel disease was higher in non-MetS Patients than MetS patients.
In our study when comparing HTN as a component of MetS patients versus HTN alone in non MetS patients the results showed that the mean GS in HTN patients in MetS was(57.32±36.86) higher than HTN non-MetS patients(21.632±1.862) with p value <0.00001* .
All our findings in our study came in agreement almost with the studies that studied the MetS and its relation with CAD
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