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العنوان
Role of marine algae against the risks of water pollutiion with cadmium in rats /
المؤلف
Haffez, Nesreen Mohamed Essam El - Din.
هيئة الاعداد
باحث / نسرين محمد عصام الدين حافظ
مشرف / أحمد الوزير معوض هجرس
مشرف / وفاء محمد السيد الخولي
مشرف / وائل محمد السيد إبراهيم
الموضوع
Marine algae - rats. Hepatotoxicity - rats. Cadmium - rats. Renal toxicity - rats.
تاريخ النشر
2013.
عدد الصفحات
p. 181 :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الحيوان والطب البيطري
تاريخ الإجازة
01/01/2013
مكان الإجازة
جامعة المنصورة - كلية العلوم - Department of Zoology
الفهرس
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Abstract

The aim of this study is to clarify the possible beneficial effects of marine algae (brown or green) in protecting liver and kidney from such dangerous effects. Premature male albino rats (Rattus norvegicus), weighing about (70±10g) were used in this study. They were divided into 6 groups; 12 rats in each half of them treated for two months and the other for four months
The obtained result can be summarized as follow:
The recorded changes during cadmium administration were:
1- Significant decrease in the food intake and water consumption with the time until the end of the experiment (120 days).
2- Decrease in the body weight as well as the relative liver and kidney weights.
3- Decrease in all tested blood parameters.
4- Increase in Cd concentration in serum, liver and kidney.
5- Decrease in serum total protein content (TP).
6- Increase in total bilirubin, ALT, AST and ALP activities.
7- Increase in serum urea, creatinine and uric acid
8- Increase in oxidative stress biomarkers as MDA and H2O2 levels in liver and kidney.
9- Decrease in GSH content and antioxidant enzymes SOD, CAT and GST activities in liver and kidney.
10- Histopathological observations: Administration of cadmium caused pathological changes in hepatic and renal architecture and this was more obvious after four months.
A desirable recovery was observed in most biological, biochemical and histopathological parameters when marine algae (brown or green) was administrated to rats supplemented with Cd. Thus, the present study suggested the benefits of adding some natural especially those having antioxidant effects to minimize the toxic effects of Cd.