الفهرس 
Hepatocellular CarcinomaOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma (HCC) accounts for 80–90% of liver cancers and is one of the most frequent carcinomas worldwide. HCC may arise both in liver cirrhosis (60–80% of HCCs) and in noncirrhotic liver, suggesting that different hepatocarcinogenetic pathways exist. The gene encoding IL1β is highly polymorphic and several diallelic Polymorphisms have been reported.
(–31T>C)IL-1β single nucleotide polymorphism was associated with a 2- to 3-fold increased risk of cancer which has been implicated as an important factor for tumor growth. Several independent lines of evidence have also suggested that genetic polymorphisms within IL-1β gene are associated with gastric cancer and HCC in HCV infection.
Matrix metalloproteinases (MMPs) are involved in tumor growth, invasion and remote metastasis in various cancers. Recently, functional gene polymorphisms in these MMPs have been found, and some reports have revealed an association between these polymorphisms and the prognosis of various cancers. The promoter region of MMP3 is characterized by a 5A/6A
polymorphism located at nucleotide position 1171 relative to the
transcriptional start site, with one allele having five adenosines (5A)and the other having six adenosines (6A). The 6A allele is associated with reduced gene expression.
IL-1β up-regulates MMP-3 transcription via activating the ERK and p38 MAPK pathways. The functional gene polymorphisms.