الفهرس 
Sickle cell anemiaOnly 14 pages are availabe for public view
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Abstract
Children with SCD, even in steady-state, have differences in several biomarkers as compared to healthy age-matched children. Those differences are related to numerous mechanisms associated with infection, inflammation and vaso-occlusion in the disease. Concerning Lipids, it was observed that changes in lipid profile in SCD patients were associated with hemolysis, inflammation and renal metabolism. In several trials it was found that the lipid profile of SCD patients is quite lower than that in subjects with normal haemoglobin.
The aim of this study was to evaluate the lipid profile in SCD and sickle thalassemia patients in correlation to various complications encountered in those patients.
A case- control study was performed in the Pediatric Hematology Clinic, Ain Shams University hospital in the period from October 2011 to June 2012.
It was included 25 patients with SCD and sickle thalassemia in steady state, and 25 age and sex- matched healthy controls.
Patients were subjected to medical history taking and revision of hospital records for history of blood transfusion, number of hospital admissions and their causes, transfusion index, number of vaso-occlusive episodes, number of strokes details of hydroxyurea theapy, packed RBCs transfusion and chelation therapy. Full clinical examination was done and laboratory investigations including CBC, lipid profile and serum ferritin.
We found a significant lower median HDL 35.6 (29.25-43.25) mg/dl (P= 0.015), median LDL 70 (54.25-81.25)mg/dl (P=0.037), mean cholesterol levels 127.96 ± 32.45 mg/dl (P= 0.038) in sickle cell patients compared to control group where HDL 44 (39.5-51) mg/dl, median LDL 81 (66.75-97.25)mg/dl, mean cholesterol levels 146.64 ± 29.5 mg/dl, with no significant difference concerning triacylglycerol. Triglycerides levels were significantly lower in patient with sickle cell disease 112 (80.5- 126.5)mg/dl compared to patients with sickle thalassemia disease 69 (52-94) mg/dl (P=0.020).