الفهرس 
CyclophosphamideOnly 14 pages are availabe for public view
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Abstract
Cyclophosphamide (CP) is a well-known alkylating agent used as antitumor drug. However, hemorrhagic cystitis, acute lung injury occurs in virtually most patients treated by CP.
In the current study, potential protective effects of antioxidants like thymoquinone (TQ), allicin and quercetin (Qur) against CP-induced lung toxicity were evaluated.
In the present study, CP (150 mg/kg) injected I.P as a single dose is capable of producing damage of lung tissues in rats.
The lung injury induced by CP can be evidenced by an decrease in the percent survival of animals compared to control non-treated group, while an increase in lung weight index (organ weight/body weight). The injury was also confirmed biochemically by significant increases in lung content of lipid hydroperoxides that paralleled the decreased in the content of total reduced glutathione. SOD activity was significantly increased. This injury may reflect the occurrence of an oxidative stress in lung following CP injection. In addition, CP produced a significant increase in the level of serum biomarkers; total protein, lactate dehydrogenase (LDH) and tumor necrosis factor-alpha (TNF-α). Moreover, histopathological examination helped to manipulate the severity of lung damage after CP.
The usefulness of some antioxidants like TQ, allicin or Qur to protect against acute lung injury may be of a particular value to be used along with CP or any like-agent which causes oxidative damage.