الفهرس 
AbstractOnly 14 pages are availabe for public view
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Abstract
Osteoarthritis (OA) is one of the most common affection of both human and animal. To date no ideal OA treatment protocol has been described. the effects of sodium pentosan polysulfate (NaPPS) administered intramuscullary (IM) for treatment of experimentally induced osteoarthritis were evaluated in 12 donkeys. OA was induced in all donkeys using repeated injection of allogenous donkey cartilage. Six donkeys received NaPPS (3 mg/kg, IM) on study days 70, 77, 84, and 91. Six control donkeys received the same volume of saline (0.9% w/v NaCl) IM on study days 70, 77, 84, and 91. Clinical, radiographic, gross, histologic, histochemical, and biochemical findings as well as synovial fluid analysis were evaluated. Marked Changes in the clinical signs, synovial fluid analysis and histopathological examination were observed. NaPPS resulted in significant improvement in clinical signs and articular cartilage healing, and no adverse effects were detected confirming that NaPPS has disease-modifying properties.