الفهرس 
coverOnly 14 pages are availabe for public view
 |  | from | 182 |  |  |
| | | from | 182 | | |
Abstract
ronchopulmonary dysplasia is the most common cause of chronic respiratory disease during infancy and despite significant progress in neonatal intensive care and increasing survival of extremely immature infants, the incidence of BPD is not decreasing. The etiology and pathology of the disease is still discussed.
This work was designed to evaluate the role of ultrasound of the lungs to diagnose and predict development of BPD. The study also assessed the level of gelatinase A (MMP-2) in the tracheal aspirate of neonates and evaluate its role in early prediction of the subsequent development of BPD in neonates.
This study included 40 neonates. Those neonates were classified into two groups according to their gestational age: full-term group and preterm group. Neonates with any congenital malformations, genetic disorders or those whose mothers had history of chorioamnionitis were excluded.
For all subjects included in this work, the following were done: full history taking, thorough clinical examination, and a group of laboratory investigation: CBC, CRP, tracheal aspiration to detect levels of gelatinase
A on day zero (first & six hours of life) and day three to
five using ELISA technique.
Also chest ultrasound was done once in the first days
after delivery and then twice weekly till discharge. Chest
radiograph was done once in the first three days and once
before discharge.
The results of the present study revealed that RDS
constitute the most common diagnosis among preterm
group, while neonatal sepsis was the most common
diagnosis among the full term group.
In our study, there was no consistent association
between G.A and development of BPD. There was equality
in full term and preterm group as for the occurrence of
BPD.
Those who were exposed to IMV and CPAP
developed BPD in 41045 with a P-value of 10111.
In our study, levels of gelatinase A (MMP-2) were
significantly lower on day zero in those who developed
BPD with a sensitivity 1115, specificity 615 and accuracy
69015. Also levels of gelatinase A on days 3-5 showed
significant decrease in the BPD group compared to non-
BPD group (P < 10111).
Gelatinase A levels on day zero was lower in those
who exposed to IMV compared to those who were exposed to CPAP alone with a P-value of 1.112.
In the present study, first week ultrasound was not
statistically significant in diagnosing BPD.
The ultrasound findings were significant in the second week of life in relation to the outcome of neonates
(P < 10111).
Our study showed also that ultrasound findings in the
third week of life were also significant and persistence of
abnormal pattern was significantly correlated to the
subsequent development of BPD (P <10111).the second
week U/S show sensitivity 111 % , specificity 955 .