الفهرس 
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Abstract
Background: Polycystic Ovary Syndrome (PCOS) is one of the most common female endocrine disorders affecting approximately 5%-10% of women of reproductive age (12 – 45 years old) and is thought to be one of the leading causes of infertility. Theprevalence of PCOS has increased with the use of different diagnostic criteria and has recently been shown to be 18% in the first community-based prevalence study based on current Rotterdam diagnostic criteria. PCOS is, by nature, a heterogeneous disorder, and the underlying cause remains unclear. There is firm evidence for a strong genetic component to the syndrome, but environmental factors, particularly dietary, are also important. Food safety is an increasingly important public health issue. Governments all over the world are intensifying their efforts to improve food safety.
Objectives:to improve food safety through study the relation between food containing estrogen like substance and the increasing number of women affected by polycystic ovary syndrome in order to improve public health.
Patients and methods:This study is a cross sectional study that includes 60 females in the childbearing period (18-40 years) that are attending the outpatient clinic complaining from irregular cycles or infertility. Women diagnosed with PCOS according to the definition set by the joint meeting of ESHRE/ASRM, in Rotterdam, 2003; fulfilling at least two of the three criteria: oligo-ovulation or anovulation; clinical and/or biochemical hyper androgenism; and polycystic ovaries on ultrasound examination with exclusion of other etiologies. Dietary questionnaire will be taken from every patient based on foods containing estrogen after consent. The aim of the questionnaire is to find –after analysis-if there is a relation between polycystic ovarian disease and some food stuffs containing estrogen like substance.A total number of 90 samples of different food stuff were collected from different areas in Giza and six October provinces. These samples were used for detection of estradiol 17-β residues in the extract.
Results: The result of this study show that the amount of all food stuffs consumed per month in grams among PCOS group was higher compared to non PCOS group. Regarding hormonal residues in different food stuffs, which is the amount of estradiol in different food stuffs per month in pg, in PCOS and Non PCOS patients, hormonal residues among PCOS group were higher compared to non PCOS group with statistically significant in between. The total amount of estrogen consumed through food (total estrogen burden) among PCOS group was higher compared to non PCOS with statistically highly significant difference.
Recommendation: Early detection and management of PCOS which seems to be a common disorder in our locality, so large multi-center screening studies are needed for our adolescent. In order to protect the health of the consumer, one of the most important principles is that foodstuffs obtained from animals treated with veterinary medicinal products must not exceed maximum residue limit (MRL) which is defined by the FAO/WHO as “the maximum concentration of residue resulting from the use of a veterinary medicinal product “ .According the Egyptian organization for standardization and quality control the maximum permissible limit of hormonal residue is 2 ng/gm of tissue (oneng = 1000 pictogram).Boiling of the chicken without skin to decrease estrogen level intake by consumers. The residue of estrogens found in fat exceeds those found in the other tissue.